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Activated mTOR and Rho pathway in DN podocytes. (A) Compared with WT and eNOS−/−, podocyte p-S6K T389 expression was increased in db/db eNOS−/− and correlated with DAAM2 expression. (B) Compared with WT and eNOS−/−, podocyte p-MYPT1 T853 expression was increased in db/db eNOS−/− and correlated with DAAM2 expression. (C) Rare active β-catenin expression in podocytes was detected in all groups.
