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. 2021 Oct 28;49(20):11643–11652. doi: 10.1093/nar/gkab899

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Published by Oxford University Press on behalf of Nucleic Acids Research 2021.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 3. — FAN1 and EXO1 protect against MSH3-dependent expansions. (A) Typical repeat PCR profiles from the brains of 6-month old WT, Fan1^-/-, Exo1^-/-, Msh3^-/- as well as Msh3^-/-Fan1^-/-and Msh3^-/-Exo1^-/- double knockout mice matched for initial repeat number. The dotted line represents the size of the original inherited allele as ascertained from the tail DNA taken at weaning. The numbers alongside some of the traces indicates the number of repeats added during the lifetime of the mouse. (B) Comparison of the number of repeats added in different organs of 6-month old WT, Fan1^-/-, Exo1^-/-, Msh3^-/- and Msh3^-/-Fan1^-/-and Msh3^-/-Exo1^-/- double knockout mice with with 168–174 repeats in the original allele. The data represent the average of five Fan1^-/- males and four males of each of the other genotypes. The error bars indicate the standard deviations of the mean. Significance was assessed using a RM two-way ANOVA (genotype and tissue as variables) with correction for multiple testing as described in the Materials and Methods. The adjusted P values of genotype effect are listed in the table.