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. 2021 Oct 28;49(20):11643–11652. doi: 10.1093/nar/gkab899

Figure 5.

Figure 5.

Loss of FANCD2 has no effect on repeat expansion. (A) Typical repeat PCR profiles from tail DNA taken at weaning (3-week tail) and different organs of 6-month old WT and Fancd2-/- mice with ∼165 repeats. The dotted line represents the size of the original inherited allele. The numbers associated with the samples from the animals at 6-months of age indicates the number of repeats added in the indicated organ during the lifetime of the mouse. (B) Comparison of the number of repeats added in different organs of 6-month old WT and Fancd2-/- mice with ∼165 repeats. The data represent the average of six WT and five Fancd2-/- male mice with 162–167 repeats. The error bars indicate the standard deviations of the mean. Significance was assessed using two-tailed unpaired t tests with correction for multiple testing as described in the Materials and Methods. No significant difference was found between the two genotypes.