Fig. 4.

Network dynamics, atrophy and network topology. (A) and (B) In a combined analysis of the two cohorts the first two principal components differed between PSP and controls. Mean activation states with PCA loadings >|0.3| are shown. (C) and (D) Component 1 correlated with subcortical volume but not frontal cortical thickness, although with no significant difference in slope. Component 2 did not correlate significantly with either frontal cortical thickness or subcortical volume. E and F) Loadings in component 2 were associated with reduced clustering coefficient and reduced weighted degree in PSP but not controls. No relationships were found with component 1.