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. 2021 Nov 4;12:769723. doi: 10.3389/fgene.2021.769723

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Copyright © 2021 Sanhueza Salas, García-Venzor, Beltramone, Capurro, Toiber and Silberman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SOX9 levels in retinas from mice with a conditional deletion of SIRT6 from the CNS. (A) Representative immunofluorescence of SOX9 levels (red) in Nes-Cre^+/+ (left panel, n = 4) and Nes-Cre^−/− (right panel, n = 5) whole retinal sections. Scale bar: 100 μm. (B) Higher magnification photos show colocalization of SOX9 with glutamine synthetase (green) in Müller cells and RPE. Scale bar, 50 μm Ganglion Cell Layer (GCL), Inner Plexiform Layer (IPL), Inner nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Retinal Pigment Epithelium (RPE). (C) Fluorescence intensity was quantified using the ImageJ program. (D) Representative Western blot of SOX9 levels from retinal extracts of Nes-Cre animals. β-actin was used for normalization. Quantification of bands was performed using the ImageJ program. Data are mean ± SE.