Figure 2.
T. cruzi-specific humoral response measured using conventional serological tests in subjects with chronic Chagas disease undergoing incomplete and complete benznidazole treatment regimens. The post-treatment/pre-treatment antibody ratios measured using ELISA (a), IHA (b) and IIF assay (c) at different timepoints after benznidazole therapy are depicted. Medians and 10–90 percentile values are shown for the incomplete (striped boxes, n = 33) and complete (white boxes, n = 58) treatment groups. Changes from baseline (Time 0) and between groups were evaluated using a linear mixed model for repeated measures. *** P < 0.001, ** P < 0.01 and * P < 0.05 compared with pre-treatment values. Pi indicates the P value of the linear mixed model with interaction between the incomplete and complete treatment regimens. E is the estimate value of the linear mixed model comparing the incomplete and complete treatment groups.