FIGURE 2.

PEX26 interactions with the peroxisomal interactome. (A) BRET-based PPI screen of PEX26 WT against a peroxisomal protein library (positive interaction, yellow bar; non-interacting, blue bar; known interaction, black frames). (B) Protein interactions with PEX26 WT are grouped with respect to peroxisomal function. (C) Integrated disease network demonstrating the relation of peroxisomal proteins (grey nodes, peroxisomal proteins; grey edges, protein-protein interactions) and peroxisome associated disorders (red nodes, disorders; red edges, phenotype gene relationships; vermiculated red line: disease-disease interactions).