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. 2021 Nov 4;12:726174. doi: 10.3389/fgene.2021.726174

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Copyright © 2021 Lotz-Havla, Woidy, Guder, Schmiesing, Erdmann, Waterham, Muntau and Gersting.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Edgetic perturbations due to missense variants in PEX26. (A) Variant specific PEX26 networks vary with respect to number and pattern of edgetic perturbations. Interacting proteins are grouped with respect to peroxisomal function (fatty acid metabolism, pink; membrane assembly, dark blue; matrix protein import, cyan; division and proliferation, violet; unknown function, grey). Disrupted interactions are depicted by a red T-arrowed edge. (B) Hierarchical cluster analysis defined subgroups of missense variants using a distance matrix algorithm. The height of the dendrogram reflects the relation of individual clusters. Three main clusters are highlighted by blue boxes.