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. 2021 Nov 4;12:719599. doi: 10.3389/fmicb.2021.719599

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Copyright © 2021 Zheng, Piao, Liu, Liu, Liu, Zhang, Ren, Liu, Zhu and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbial diversity shows slight difference between healthy control and primary hypertension patients with antihypertension medications. (A) Gene count comparison between the two groups. (B) Venn comparison of the shared gene numbers and unique gene numbers between the two groups. (C) α-Diversity analysis (Shannon index) based on genus, species, and ortholog profile in the two groups. (D) Principal component analysis (PCA) of β-diversity analysis based on genus, species, and orthologs profile between the two groups. Ctrl, healthy control group, n = 8. HBP, primary hypertension patient group who took antihypertension medications before testing metagenomics, n = 30. Gene level, i.e., ortholog level. *p < 0.05 by one-tailed Mann–Whitney U-test.