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VSD-II in the activated-state structure and resting-state model. (A) Matrix of contact variants, in addition to contacts within VSD-II, slows contacts IIS4-5/IIIS5 and IIS5/IS4 (B,C) VSD-II in the activated-state cryo-EM structure (B) and resting-state model (C). Residues from set w54 and their contacts are indicated with green and red labels, respectively. VSD-II Section for more details.
