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. 2021 Nov 4;12:756415. doi: 10.3389/fphar.2021.756415

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Copyright © 2021 Korkosh, Zaytseva, Kostareva and Zhorov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Matrices of contact variants and structures of VSD-III and VSD-VI. (A) Matrix of contact variants of VSD-III. (B,C) VSD-III in the activated-state cryo-EM structure (B) and resting-state model (C). Residues from set w54 and their contacts are indicated with green and red labels, respectively. See section VSD-III for more detail. (D) Matrix of contact variants of VSD-IV. (E) Activated-state structure of VSD-IV. Residues from set w54 and their contacts are indicated with green and red labels, respectively. See section VSD-IV for more details.