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. 2021 Nov 4;12:756415. doi: 10.3389/fphar.2021.756415

TABLE 2.

PDVs and their contact variants in the open-PD model ^a .

PDV		Contacts
Variant	Syndrome	Variant	Syndrome	Significance
^IIIS6N¹⁴⁶³K	NP	^IIS6S⁹⁴°C	BrS1	VUS
		^IIS6S⁹⁴¹C	CP	VUS
		N	LQT3	P
^IIIS6F¹⁴⁶⁵L	LQT3	^IIIS5A¹³³⁰P	LQT3	NP
^IIIS6F¹⁴⁶⁵L	LQT3	T	BrS1, LQT3, More	P/LP
^IIIS6I¹⁴⁶⁶T	NP, A	^IIS6S⁹⁴¹C	CP	VUS
V	NP	N	LQT3	P
^IIIS6V¹⁴⁶⁸A	A, BrS1,NP	^IIIS5A¹³³⁰P	LQT3	NP
^IIIS6V¹⁴⁶⁸A	A, BrS1,NP	T	BrS1, LQT3, More	P/LP

^a

Contacts in the cryo-EM structure (Table 1) are not shown.