TABLE 5.

PDVs and their contacts in resting VSDs ^a .

PDV		Contacts
Variant	Syndrome	Variant	Syndrome	Signif.
IS1I141N	BrS1	IS4V223A	A	LB
F	NP	L	BrS1	NP
IS2R179P	BrS1	IS2-S3H184Q	BrS1, CVP	CIP
Q	BrS1	IS2-S3A185T	BrS1, LQT3, A	CIP
		V	BrS1, A	VUS
IS4R219C	A, BrS1	IS2E161Q	BrS1	NP
H	BrS1, DCM	K	BrS1	CIP
P	LQT3, BrS1, More
IIS3E795K	BrS1	IIS4R808P	LQT3	NP
		C	A	VUS
		H	LQT3, A	VUS
IIS4-S5L825P	BrS1	IIS4A819P	BrS1	VUS
IIS5I848F	A, BrS1, LQT3	IS4V223A	A	LB
		L	BrS1	NP
		IS4L227P	BrS1	CIP
IIIS4R1306L	CVP	IIIS3I1278N	LQT3	NP
H	NP, BrS1
C	A
S	BrS1
IVS2C1575Y	A, BrS1	IVS3D1595H	BrS1, LQT3, More	LP
S	A	N	BrS1, More	P
IVS4-S5I1643L	NP	IS5D252V	BrS1	VUS
		IVS3I1637T	NS	VUS

^aContacts in the cryo-EM structure are shown in Table 4.