TABLE 6.

PDVs whose missense contact variants in the cryo-EM structure or models are not listed in ClinVar.

#	PDV		Exposure	Comment
	Varianta	Syndromeb,c
1	IS6V396L	BrS11,3,4	Lipids	Tight contacts withIS5F264 IP1L365 and IP1L368
2	IIS1L732P	BrS1
3	IIS1-S2L736P	BrS1	Extracellular	Loop Flexibility
4	IIS1-S2H738P	BrS1	Extracellular	Loop Flexibility
5	IIS3M794T	NP	Lipids
6	IIS4-S5G833R	LQT-3,NP,A, BrS17	Lipids
7	IIS5V924F	NP	Lipids
8	IIIS1R1195C	BrS1	Cytoplasm	R1195 may reach G1262 “
9	IIIS1R1195H	“	Cytoplasm
10	IIIS2-S3G1262S	BrS1, LQT-3, PFHB1,3,11,12	Cytoplasm	Loop flexibility
11	IIIS6I1448L	A, BrS1, CVP1,3,4	Lipids

^a-e See footnotes to Table 1.