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. 2021 Nov 4;9:754205. doi: 10.3389/fbioe.2021.754205

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Copyright © 2021 Wang, Li, Wang, Liu, Cui, Liu, Ren, Zhan, Li, Wu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SCHEME 1 — The illustration of the BMP-2/OPG-loaded 3D-printed composite scaffolds and their application as scaffolds to promote osseointegration in osteoporosis. BMP-2, bone morphogenetic protein-2; OPG, osteoprotegerin.