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. 2021 Nov 4;12:760468. doi: 10.3389/fimmu.2021.760468

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Copyright © 2021 Carranza, Herrera, Guzmán-Beltrán, Salgado-Cantú, Salido-Guadarrama, Santiago, Chávez-Galán, Gutiérrez-González and González

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The behavior of each group of patients, showing the evolution of each patient according to the ΔC_T values during the periods of time. (A) The transitions model comparing six times. Upregulation or downregulation in the ΔC_T value between time points is illustrated in a heatmap. Blue: upregulation in the ΔC_T value in the next time point or the target time point; gray: downregulation in the ΔC_T Cs value, and black: no transition between time points. (B) MDR-TB group and (C) MDR-TB-T2DM (-) group. The table includes results of the transition probabilities of the two groups: MDR-TB, MDR-TB-T2DM(-). Each group is divided at the same time point into 2 subgroups according to the ΔC_T values of transition: upregulated or downregulated.