Table 1.
Characteristics of the study participants.
| Patients (n=26) | Healthy controls (n=15) | P value | |
|---|---|---|---|
| Age, yr | 43.5 (19–77) | 45 (27–61) | 0.6859 |
| Sex, male (%) | 18 (69.2) | 10 (66.6) | >0.9999 |
| BMI | 23.2 (17-27) | 26 (23-33) | 0.0050 |
| Comorbidities | |||
| Diabetes (%) | 9 (34.5) | – | – |
| Alcoholism (%) | 9 (34.5) | – | – |
| Smoking (%) | 2 (7.7) | – | – |
| Malnutrition (%) | 15 (5.77) | – | – |
| Pulmonary Tuberculosis | |||
| RR/MDR-TB (%) | 3 (15.4) | – | – |
| MDR-TB (%) | 21 (73) | – | – |
| XDR-TB (%)TB Treatment | 2 (7.7) | – | – |
| Individualized *(%) | 9 (42.8) | – | – |
| Clinical data | |||
| LeukocytesWBC count, x103/mm3 | 9.7 (4.3–18.8) | ||
| Neutrophil count, x103/mm3 | 7.4 (1.7-17.3) | ||
| Lymphocyte count, x103/mm3 | 1.6 (0.9–2.4) | ||
| Hematocrit % | 41.2 (27.2-52.8) | ||
| Hemoglobin g/ml | 13.6 (9.4-17.7) | ||
| NLR ratio | 4.8 (0.9-18.8) | ||
| Metabolic characteristics | |||
| HbA1c % T2DM | 9.2 (5.5-13.5) | ||
| Glucose, mg/dl | 99 (75-525) | ||
| Blood Chemistry Profile | |||
| Creatinine, mg/dl | 0.76 (0.51-1.1) | ||
| BUN, mg/dl | 10 (5.8-20) | ||
| Albumin, mg/dl | 3.6 (2.3-4.4) | ||
| Urea, mg/dl | 22 (12.4-42) | ||
| Renal functionMDRD ml/min/1.73 m2 | 109.3 (67-7167.3) | ||
| CKD/EPI ml/min | 104 (64-134) | ||
| CrCL ml/min | 102.3 (49-209.2) | ||
| Nephrotoxicity | 17.4% | ||
| Hearing damage | 35% |
*Individualized include the drugs: standard antibiotics and others such as amoxicillin, clavulanic acid, ceftriaxone, linezolid,
clofazimine and dalamanid. BMI, Body Mass Index; RR/MDR-TB, Rifampicin-Resistant-MDR TB; MDR-TB,
Multidrug-resistant TB; XDR-TB, Extensively drug-resistant TB; WBC, White Blood Cell; NLR,
Neutrophil-Lymphocyte Ratio; HbA1c, hemoglobin A1c; BUN, Blood Urea Nitrogen; MDRD,
Modification of Diet in Renal Disease; CKD/EPI, Chronic Kidney Disease Epidemiology Collaboration;
CrCL, Creatinine clearance rate.