Fig. 8.

Schematic diagram of related hypothesis. A. Schematic diagram of “Autophagy, iron ptosis and apoptosis always overlap and interfere with each other” and the protein and signal pathway hypothesis related to the study. B. Schematic diagram showing how EGCG pretreatment protected cardiomyocytes against Dox-induced ferroptosis. EGCG pretreatment upregulated the expression and phosphorylation of AMPKα2 and activated adaptive autophagy, thereby decreasing iron accumulation, inhibiting excess ROS generation and abnormal lipid metabolism, increasing energy supply, and maintaining mitochondrial function, ultimately protecting the myocardium against Dox-induced ferroptosis.