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. 2021 Nov 4;11:773078. doi: 10.3389/fonc.2021.773078

Table 4.

Multivariate analysis of inflammatory and clinical characteristics in relation to 5-years LRRFS, DFS in ER+ HER2- early breast cancers not treated with chemotherapy (n=999).

Variables LRRFS Variables LRRFS DFS
HR 95%CI p HR 95%CI p HR 95%CI p
PLR LMR
Low 0.42 0.22-0.81 0.009 Low 2.20 1.11-4.37 0.02 2.10 1.17-3.74 0.01
High Ref. High Ref. Ref.
Age 1.03 1.01-1.06 0.01 Age 1.03 1.00-1.06 0.03 1.04 1.01-1.06 0.002
pT pT
pT1 1.16 0.38-3.57 0.80 pT1 1.14 0.38-3.48 0.81 0.82 0.37-1.79 0.61
pT2 Ref. pT2 Ref. Ref.
pN pN
pN0 0.76 0.33-1.75 0.52 pN0 0.77 0.34-1.77 0.54 0.62 0.33-1.18 0.14
pN1 Ref. pN1 Ref. Ref.
Ki67 Ki67
≤14% 0.49 0.23-1.05 0.07 ≤14% 0.58 0.27-1.23 0.16 0.48 0.26-0.88 0.01
>14% Ref. >14% Ref. Ref.
Grade Grade
G1/2 1.13 0.36-3.55 0.83 G1/2 1.02 0.32-3.21 0.98 0.90 0.39-2.07 0.80
G3 Ref. G3 Ref. Ref.
Histological type Histological type
Lobular 0.60 0.23-1.58 0.30 Lobular 0.65 0.25-1.71 0.38 0.61 0.27-1.38 0.24
Others 1.10 0.33-3.72 0.87 Others 1.14 0.34-3.83 0.83 0.78 0.24-2.56 0.68
Ductal Ref. Ductal Ref. Ref.