Table 1.

Viral replication and protein expression levels of each genotype.

	Genotype
	A2	B2	C1	D1	F1b
cccDNA (Copies/cell)	2.73	4.71**	3.34ξ	3.13ξ	5.34** ## &&
pgRNA (Copies/μl)	9.31×102	9.32×104** ξξ	4.1×104** ξξ	3.58×104** ξξ	6.58×104** ξξ ## &&
pgRNA (Copies/μl)	1.02×105	3.48×102**	6.25×103**	5.02×104** ξξ ##	1.54×104** ξξ ## &&
Intracellular DNA (OD)	3.89×103	1.15×104**	2.38×103ξξ	7.16×103** ξξ ##	8.44×103** ξξ ##
Extracellular DNA (Copies/μl)	6.59×105	7.38×105	4.74x105ξ	6.59×105	5.47×105
Extracellular HBsAg (IU/ml)	99.7	108.67	79.76	18.94** ξξ ##	145.56** ξξ ## &&
Intracellular HBsAg (IU/ml)	95.9	69.04	18.22** ξξ	18.21** ξξ	12.47** ξξ
Extracellular HBeAg (S/Co)	26.3	38.66*	57.07** ξξ	14.73** ξξ ##	6.58** ξξ** ξξ ##
Intracellular HBeAg (S/Co)	27.9	8.65**	5.52**	2.76**	1.47**

Shown values represent the mean of three independent experiments. ^*, difference in relation to gtA2; ^ξ, difference in relation to gtB2; ^#, difference in relation to gtC1 and ^&, difference in relation to gtD1. One symbol: p<0.005 and two symbols: p<0.0001.