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. 2021 Nov 4;15:752594. doi: 10.3389/fnins.2021.752594

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Copyright © 2021 Sanchez-Varo, Sanchez-Mejias, Fernandez-Valenzuela, De Castro, Mejias-Ortega, Gomez-Arboledas, Jimenez, Sanchez-Mico, Trujillo-Estrada, Moreno-Gonzalez, Baglietto-Vargas, Vizuete, Davila, Vitorica and Gutierrez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased hippocampal synaptic markers in young APP/PS1 mice. (A) Representative Western blots for several synaptic markers in 2-, 4-, and 6-month-old APP/PS1 (n = 6/age) and WT (n = 4/age) hippocampal samples. Quantitative analysis showed a significant and progressive decrease in the postsynaptic marker PSD95 (B), and the presynaptic markers SYN (C) and VGAT (D) from 4 to 6 months of age in the double transgenic mice compared to age-matched WT. Moreover, levels of VGLUT1 were significantly reduced at 6 months of age (E). Represented data were normalized respect to 2-month-old WT samples. Tukey’s test: *p < 0.05.