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. 2021 Nov 4;15:752594. doi: 10.3389/fnins.2021.752594

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Copyright © 2021 Sanchez-Varo, Sanchez-Mejias, Fernandez-Valenzuela, De Castro, Mejias-Ortega, Gomez-Arboledas, Jimenez, Sanchez-Mico, Trujillo-Estrada, Moreno-Gonzalez, Baglietto-Vargas, Vizuete, Davila, Vitorica and Gutierrez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plaque-associated dystrophic neurites as a source of Aβ42. TEM images from Aβ42-immunogold labeled hippocampus from 6-month-old APP/PS1 mice. (A) Aβ42-labeling evidenced the presence of this amyloid isoform, not only within the plaque (asterisk), but also in the membrane of periplaque dystrophic neurites (B–H). Arrows in the corresponding details (C,E,G) and (H,I) point to the gold particles. Inset in panel (H) depicts amyloid fibers intermingled with a dystrophic process. (I,J) Aβ42-positive swollen axonal/presynaptic neuronal processes were filled with vesicular compartments related to autophagy-lysosomal pathway [details at higher magnification in panels (K,L)], which were positive to Aβ42. Scale bars, (A) 1 μm; (B–D,F,H–L) 0.2 μm; (E–G), inset in panel (H) 0.1 μm.