. 2021 Aug 19;3(4):fcab182. doi: 10.1093/braincomms/fcab182

Table 4.

Continuous and binary variables compared across eigenbrains

Continuous variables beta coefficients (bold = significant)
Variable	R ²	_Adj R ²	N		EB1		EB2	EB3	EB4	EB5	EB6	EB7	EB8	P-value			P-value FDR
Age of onset^a	0.52	0.47	91		−0.14		−0.02	0.21	0.48	0.01	0.21	−0.37	0.18	<0.001			<0.001
Education	0.14	0.05	91		−0.01		−0.17	0.23	0.13	0.17	0.07	0.06	−0.04	0.13			0.94
STMS	0.41	0.35	83		−0.39		0.12	0.39	0.06	0.14	0.17	0.28	−0.25	<0.001			<0.001
Calculation	0.40	0.33	83		−0.15		0.20	0.25	0.24	0.20	0.21	0.22	−0.31	<0.001			<0.001
Construction	0.27	0.19	81		−0.20		−0.21	0.23	0.23	0.20	0.13	0.13	−0.20	<0.01			<0.05
DRS-2 Memory	0.43	0.27	39		−0.40		−0.31	0.39	−0.01	0.01	0.06	0.35	−0.29	<0.05			0.33
DRS-2 Total	0.57	0.46	39		−0.31		−0.27	0.58	0.10	0.11	−0.01	0.45	−0.38	<0.001			<0.05
Block design	0.52	0.39	42		−0.37		−0.48	0.51	0.21	−0.03	−0.04	−0.07	−0.15	<0.01			<0.05
Visual Rep. I	0.40	0.27	46		−0.14		−0.21	0.61	0.20	0.03	−0.13	0.16	−0.23	<0.01			0.15
Rey-O	0.38	0.26	51		−0.47		−0.25	0.48	0.21	−0.06	−0.10	−0.02	−0.17	<0.01			0.10
Trails A	0.53	0.45	55		−0.52		−0.10	0.62	0.27	−0.19	−0.04	0.27	−0.22	<0.001			<0.001
Trails B	0.38	0.28	55		−0.35		−0.11	0.47	0.38	−0.07	0.08	0.11	−0.10	<0.01			<0.05
COWAT	0.31	0.17	48		−0.23		−0.11	0.38	0.07	0.17	0.01	0.34	−0.35	<0.05			0.40
Category Fluency	0.42	0.31	50		−0.21		0.02	0.56	−0.11	0.19	0.20	0.25	−0.32	<0.01			<0.05
BNT	0.34	0.16	38		−0.14		−0.32	0.47	−0.05	−0.08	0.15	0.23	−0.39	0.10			0.91

Binary variables odds ratio (bold = significant)

Variable				N		EB1	EB2	EB3	EB4	EB5	EB6	EB7	EB8		P-value	P-value FDR

Sex^b				91		1.03	1.48	0.50	0.92	0.91	0.66	1.02	0.74		0.06	0.14
Environmental agnosia				62		2.15	2.88	0.67	0.55	0.76	0.99	1.30	1.06		0.11	0.14
Apperceptive prosopagnosia				48		1.30	2.45	1.22	2.07	1.11	0.57	0.44	1.71		<0.05	0.14
Aphasia				60		2.94	0.47	0.22	0.95	0.58	0.50	1.02	1.61		<0.001	<0.01
Apraxia				66		2.14	0.96	0.41	0.35	0.50	1.20	1.45	1.51		<0.05	<0.05
Memory loss				91		4.48	1.67	0.11	3.16	0.21	0.50	1.53	3.32		<0.05	<0.01
Myoclonic jerks				33		1.36	1.99	0.10	1.54	0.80	2.97	2.07	9.60		<0.001	<0.01

Negative number indicates younger age, and positive number indicates older age.

Odds ratio for male.

BNT, Boston naming test; COWAT, controlled word association test; DRS-2, dementia rating scale 2; EB, eigenbrain; FDR, false discovery rate; Rey-O, Rey-Osterrieth complex figure; STMS, short test of mental status.