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Neuronal differentiation of B-KSR1 PC12 cells requires MEK-MAPK activity. Vector-transfected and B-KSR1-expressing PC12 cells were left untreated or treated for 3 h with the MEK inhibitor PD98059 or with the Trk-NGF receptor inhibitor K252a. Cells were then stimulated with NGF (50 ng/ml) or EGF (100 ng/ml) and photographed 2 days after treatment. The experiment was repeated twice with similar results.
