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. 2021 Nov 4;8:747453. doi: 10.3389/fcvm.2021.747453

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Copyright © 2021 Siegel, Bender, Chalupsky, Heger, Rieder, Trummer, Wengenmayer, Duerschmied, Bode and Diehl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular vesicle (EV) concentration in patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO) compared to patients with ST-elevation myocardial infarction (STEMI). (A) Total Annexin V⁺ EV/ml, (B) CD61⁺ (platelet) EV/ml, (C) caveolin-3⁺ (cardiomyocyte) EV/ml, (D) CD45⁺ (leukocyte) EV/ml, (E) CD235a⁺ (erythrocyte) EV/ml, (F) CD62E⁺ (endothelial) EV/ml. EV isolation, analysis and quantification were performed as described in the Materials and Methods section. Data are presented as mean±SEM. p-values were calculated by an unpaired Student's t-test, p ≤ 0.05 was considered significant, ns – not significant.