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. 2021 Nov 8;47(1):10. doi: 10.3892/or.2021.8221

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Copyright: © Frazzi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — SPG20 is epigenetically regulated in human PBMCs. (A) Methylation profile of the selected targets in four representative PBMCs from healthy donors. (B) Overall methylation profiles of 20 PBMCs. UM corresponds to a % of demethylation ≥91%; lower percentages are specified in each box. (C) SPG20 and DNMT1 protein levels in 20 representative PBMCs from healthy donors (data are representative of a total of 27 independent PBMCs samples). SPG20, spastic paraplegia 20; PBMCs, peripheral blood mononuclear cells; UM, unmethylated; DNMT1, DNA methyltransferase 1; KLF4, Krüppel-like factor 4; DAPK1, death associated protein 1.