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. 2021 Nov 3;25(1):4. doi: 10.3892/mmr.2021.12520

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Copyright: © Song et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — EPCs ameliorate the oxidative stress and inflammation induced by Ang II in PRKs via secreted MVs. (A) Flow cytometry analysis to determine the effect of EPC-MVs on ROS generation in Ang II-treated PRKs. ELISA results of the effect of EPC-MVs on the levels of (B) MDA, (C) GSH and (D) SOD in Ang II-treated PRKs. The effect of EPC-MVs on the levels of (E) IL-1β, (F) IL-6 and (G) TNF-α secreted by Ang II-treated PRKs. *P<0.05 vs. Control; ^#P<0.05 vs. Ang II. Ang II, angiotensin II; ROS, reactive oxygen species; EPCs, endothelial progenitor cells; PRKs, primary rat kidney cells; MVs, microvesicles; MDA, malondialdehyde; GSH, glutathione; SOD, superoxide dismutase.