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. 2021 Nov 5;25(1):6. doi: 10.3892/mmr.2021.12522

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Copyright: © Bian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Treatment of vitiligo by NB-UVB is mediated by Nrf2/HO-1 signaling. The (A) Nrf2/HO-1 signaling and (B) expression of Ca²⁺ channels was examined by western blotting. (C) ER stress-related proteins levels detected by western blotting. (D) The levels of diagnostic markers of vitiligo were measured by ELISA. All the data are represented as the mean ± standard deviation (n=3). *P<0.05. NB-UVB, narrow band ultraviolet B; Nrf2, nuclear factor erythroid 2 like 2; HO-1, heme oxygenase 1; Trx-1, thioredoxin-1; Con, mice were treated with Vaseline only; VIT, mice in vitiligo model group treated with 40% monobenzone cream; NUA, mice treated with narrow band ultraviolet B and adipose-derived stem cells together; NUAM, vitiligo model treated with NB-UVB/ADSCs and Nrf2 inhibitor ML385.