TABLE III.
Influence of Rat Dosing Schedule on Maximum Mean MNHEP Frequency
| Chemical | Dosing protocol | Harvest day | Max. daily dose (mg/kg/day); Total exposure (mg/kg) | Max. Mean % MNHEPa | Study No., citation |
|---|---|---|---|---|---|
| Cisplatin | 3 day × 1 cycle | 7 | 250; 750 | 0.61 | LR180102, this article |
| 3 day × 3 cycles | 21 | 250; 2250 | 0.36 | LR180123, this article | |
| Diethylnitrosamine | 3 day × 1 cycle | 7 | 40; 120 | 1.36 | LR180306, this article |
| 3 day × 3 cycles | 21 | 40; 360 | 1.34 | LR180227, this article | |
| 28 day | 29 | 15; 420 | 1.28 | LR170717, Khanal et al. (2018) | |
| 1,2-Dimethylhydrazine | 3 day × 1 cycle | 7 | 15; 45 | 2.49 | LR180327, this article |
| 3 day × 3 cycles | 21 | 15; 135 | 2.30 | LR180206, this article | |
| Dimethylnitrosamine | 3 day × 1 cycle | 7 | 10; 30 | 0.68 | LR181016, this article |
| 3 day × 3 cycles | 21 | 10; 90 | 0.85 | LR181113, this article | |
| 2,6-Dinitrotoluene | 3 day × 1 cycle | 7 | 100; 300 | 0.37 | LR180612, this article |
| 3 day × 3 cycles | 21 | 100; 900 | 0.43 | LR180821, this article | |
| Quinoline | 3 day × 1 cycle | 7 | 125; 375 | 0.65 | LR171205, this article |
| 3 day × 1 cycle | 7 | 125; 375 | 0.46 | LR170822, Avlasevich et al. (2018) | |
| 3 day × 3 cycles | 21 | 125; 1125 | 0.97 | LR180320, this article | |
| 14 day | 15 | 100; 1400 | 0.62 | LR171002, Avlasevich et al. (2018) | |
| Vinblastine | 3 day × 1 cycle | 7 | 0.25; 0.75 | 0.38 | LR180605, this article |
| 3 day × 3 cycles | 21 | 0.175; 1.575 | 0.27 | LR180710, this article |
Abbreviation: MNHEP = micronucleated hepatocyte.
a
As a point of reference, mean %MNHEP for vehicle control rats is generally within the range 0.1–0.25.