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. 2021 Nov 17;158(1):1–9. doi: 10.1001/jamadermatol.2021.4724

Table 3. Estimates of Point Prevalence of Vitiligo.

Participants Vitiligo prevalence estimate, % (95% CI)
Overall Nonsegmental Segmental
Diagnosed and undiagnosed combineda
Self-reported 1.38 (1.26-1.49) 0.77 (0.68-0.85) 0.61 (0.53-0.69)
Clinician adjudicatedb 0.76 (0.68-0.84) 0.58 (0.49-0.66) 0.18 (0.15-0.21)
Boundc
Lower 0.76 (0.67-0.84) 0.57 (0.49-0.66) 0.18 (0.15-0.21)
Upper 1.11 (1.01-1.21) 0.84 (0.74-0.95) 0.27 (0.23-0.31)
Diagnosed
Self-reported 0.77 (0.68-0.85) 0.48 (0.41-0.55) 0.28 (0.23-0.33)
Clinician adjudicatedb,c 0.46 (0.39-0.52) 0.37 (0.30-0.43) 0.09 (0.07-0.11)
Boundd
Lower 0.46 (0.39-0.52) 0.37 (0.30-0.43) 0.09 (0.07-0.11)
Upper 0.61 (0.54-0.69) 0.49 (0.41-0.56) 0.12 (0.10-0.15)
Undiagnosed
Self-reported 0.61 (0.54-0.69) 0.29 (0.23-0.34) 0.33 (0.27-0.38)
Clinician adjudicatedb,c 0.29 (0.24-0.34) 0.21 (0.15-0.26) 0.08 (0.06-0.11)
Boundd
Lower 0.29 (0.24-0.34) 0.20 (0.15-0.26) 0.08 (0.06-0.11)
Upper 0.50 (0.43-0.57) 0.36 (0.29-0.43) 0.15 (0.12-0.17)
a

Owing to within-group weighting, the sum of the individual diagnosed and undiagnosed estimates may differ slightly from the total estimates.

b

Photographs were uploaded for clinician adjudication by 71 participants with self-reported diagnosed vitiligo and 42 participants with self-reported undiagnosed vitiligo. There was moderate agreement among the 3 expert dermatologists (Fleiss κ = 0.52; P < .001). Clinician-adjudicated vitiligo diagnoses were further adjudicated for nonsegmental and segmental vitiligo classification.

c

Nonsegmental and segmental clinician-adjudicated estimates are adjusted to account for 54.5% of self-reported segmental vitiligo diagnoses being adjudicated as segmental and 100% of self-reported nonsegmental vitiligo diagnoses being adjudicated as nonsegmental.

d

Sensitivity analysis results: lower bound, indeterminate diagnoses were classified as nonvitiligo diagnoses, and upper bound, indeterminate diagnoses were classified as vitiligo diagnoses.