Table 3. Estimates of Point Prevalence of Vitiligo.
Participants | Vitiligo prevalence estimate, % (95% CI) | ||
---|---|---|---|
Overall | Nonsegmental | Segmental | |
Diagnosed and undiagnosed combineda | |||
Self-reported | 1.38 (1.26-1.49) | 0.77 (0.68-0.85) | 0.61 (0.53-0.69) |
Clinician adjudicatedb | 0.76 (0.68-0.84) | 0.58 (0.49-0.66) | 0.18 (0.15-0.21) |
Boundc | |||
Lower | 0.76 (0.67-0.84) | 0.57 (0.49-0.66) | 0.18 (0.15-0.21) |
Upper | 1.11 (1.01-1.21) | 0.84 (0.74-0.95) | 0.27 (0.23-0.31) |
Diagnosed | |||
Self-reported | 0.77 (0.68-0.85) | 0.48 (0.41-0.55) | 0.28 (0.23-0.33) |
Clinician adjudicatedb,c | 0.46 (0.39-0.52) | 0.37 (0.30-0.43) | 0.09 (0.07-0.11) |
Boundd | |||
Lower | 0.46 (0.39-0.52) | 0.37 (0.30-0.43) | 0.09 (0.07-0.11) |
Upper | 0.61 (0.54-0.69) | 0.49 (0.41-0.56) | 0.12 (0.10-0.15) |
Undiagnosed | |||
Self-reported | 0.61 (0.54-0.69) | 0.29 (0.23-0.34) | 0.33 (0.27-0.38) |
Clinician adjudicatedb,c | 0.29 (0.24-0.34) | 0.21 (0.15-0.26) | 0.08 (0.06-0.11) |
Boundd | |||
Lower | 0.29 (0.24-0.34) | 0.20 (0.15-0.26) | 0.08 (0.06-0.11) |
Upper | 0.50 (0.43-0.57) | 0.36 (0.29-0.43) | 0.15 (0.12-0.17) |
Owing to within-group weighting, the sum of the individual diagnosed and undiagnosed estimates may differ slightly from the total estimates.
Photographs were uploaded for clinician adjudication by 71 participants with self-reported diagnosed vitiligo and 42 participants with self-reported undiagnosed vitiligo. There was moderate agreement among the 3 expert dermatologists (Fleiss κ = 0.52; P < .001). Clinician-adjudicated vitiligo diagnoses were further adjudicated for nonsegmental and segmental vitiligo classification.
Nonsegmental and segmental clinician-adjudicated estimates are adjusted to account for 54.5% of self-reported segmental vitiligo diagnoses being adjudicated as segmental and 100% of self-reported nonsegmental vitiligo diagnoses being adjudicated as nonsegmental.
Sensitivity analysis results: lower bound, indeterminate diagnoses were classified as nonvitiligo diagnoses, and upper bound, indeterminate diagnoses were classified as vitiligo diagnoses.