Table 1.

Set times of Synthecure with various antimicrobials and combinations.

Antibiotic(s)/antifungal	Dose	Powder (P)/	Avg mix	Avg set	Observations
	(mg)	liquid (L)	time (min:s)	time (min:s)
Control	n/a	n/a	0:30	4:10
Amikacin	500	P	0:27	5:35	Easy, smooth mix.
Amphotericin B	250	P	0:52	5:58	Longer to mix into a smooth paste. Mats ok.
Cefazolin	1000	P	0:51	4:41	Thicker paste, doughy. Spreads ok into mat.
Clarithromycin	200	P	0:38	4:30	Smooth mix and mat.
Clindamycin	900	P	0:30	7:03	Slightly runny. Wait 2 min to mat.
Fluconazole	400	P	0:36	4:20	Chalky. Spread into mat quickly.
Gentamicin	240	L	0:25	6:15	Runny. Wait 2 min to mat.
Gentamicin	500	P	0:45	5:48	Easy mix, smooth paste.
Meropenem	500	P	0:43	14:07	Dry mix, comes out of mat at 10 min. Sets on table top.
Rifampin	600	P	0:35	4:23	Need to mix and plate fast.
Tobramycin	240	L	0:22	9:30	Runny. Wait 3 min to mat.
Vancomycin	1000	P	0:40	3:58	Coarse, doughy. Be firm with spatula when matting.
Cefazolin/Gentamicin	1000/240	P/L	0:25	6:57	Easy to mix. Slightly runny. Easy to mat.
Cefazolin/Tobramycin	1000/240	P/L	0:25	9:25	Easy mix.
Clindamycin/Tobramycin	900/240	P/L	0:23	13:32	Runny. Wait 2 min to mat.
Vancomycin/Fluconazole	1000/400	P/P	0:38	4:40	Smooth paste. Easy to mat.
Vancomycin/Gentamicin	1000/240	P/L	0:45	7:44	Runny. Wait 2 min to mat.
Vancomycin/Tobramycin	1000/240	P/L	0:45	7:19	Runny. Wait 2 min to mat.
Clindamycin/Fluconazole/ Tobramycin	900/400/240	P/P/L	0:30	14:30	Sets well. Easy to mix.
Vancomycin/Amphotericin B/ Tobramycin	1000/250/240	P/P/L	0:35	8:13	Runny to start, but do not wait to mat.
Vancomycin/Fluconazole/ Tobramycin	1000/400/240	P/P/L	0:32	8:36	Runny to start. Wait 4 min to mat.
Vancomycin/Rifampin/ Tobramycin	1000/600/240	P/P/L	0:45	10:40	Runny to start. Mild increase in volume. Do not wait to mat.

n/a: not applicable.