Functionalization on the pyrazole nitrogens.
| ||||
|---|---|---|---|---|
| Entry | R 1 | R 2 | R 3 | Percentage reduction of c-di-GMP |
| 44 | H |
|
H | 40% |
| 32 | Ac | H | Ac | 0% |
| 33 | H | Ac | Ac | 0% |
| 37 | H |
|
H | 0% |
| 40 | H |
|
H | 0% |
| 36 | H |
|
H | 0% |
| 41 | H |
|
H | 0% |
| 39 | H |
|
H | 0% |
| 38 | H |
|
H | 0% |
| 43 | H |
|
H | 0% |
| 42 | H |
|
H | 0% |
| 37 | H | Me | H | 0% |