Table 2.

Linear Mixed Effects Model Estimates of Cytokines and Cognitive Decline in the SALSA, n=1,337

		Crude Models			IP Weighted Models			Cortisol Interaction Models
	Variable	Estimate	95%	CI	Estimate	95%	CI	Estimate	95%	CI	interaction p-value
Interleukin - 6	Intercept	1.88	1.83	1.94	1.94	1.88	2.00	2.05	1.73	2.37
	IL-6	0.13	0.09	0.16	0.09	0.06	0.13	−0.16	−0.36	0.04
	IL-6*Age	0.00	−0.01	0.01	0.01	0.00	0.02	0.04	−0.03	0.10
	Age	0.01	−0.01	0.02	0.01	−0.01	0.02	−0.09	−0.19	0.01
	Age2	0.00	0.00	0.00
	Cortisol							−0.04	−0.17	0.08
	Age*Cortisol							0.04	0.00	0.08
	IL-6*Cortisol							0.10	0.03	0.18	0.0091
	IL-6*Age*Cortisol							−0.01	−0.04	0.01	0.3503
Tumor Necrosis Factor - alpha	Intercept	1.84	1.76	1.92	1.95	1.86	2.03	1.74	1.33	2.16
	TNF-alpha	0.17	0.11	0.23	0.09	0.03	0.16	0.10	−0.23	0.43
	TNF-alpha*Age	0.00	−0.02	0.01	0.01	−0.01	0.03	−0.07	−0.17	0.04
	Age	0.02	−0.01	0.04	0.01	−0.01	0.03	0.04	−0.09	0.17
	Age2	0.00	0.00	0.00
	Cortisol							0.08	−0.08	0.25
	Cortisol*Age							−0.01	−0.06	0.04
	TNF-alpha*Cortisol							−0.01	−0.14	0.12	0.9297
	TNF-alpha*Age*Cortisol							0.03	−0.01	0.07	0.1698
C-reactive Protein	Intercept	2.02	1.99	2.05	2.04	2.00	2.08	1.98	1.76	2.19
	CRP	0.02	0.00	0.05	0.02	0.00	0.04	−0.16	−0.28	0.04
	CRP*Age	0.00	−0.01	0.00	0.00	−0.01	0.00	−0.01	−0.04	0.03
	Age	0.02	0.01	0.03	0.02	0.01	0.03	−0.04	−0.10	0.02
	Age2	0.00	0.00	0.00
	Cortisol							0.02	−0.06	0.11
	Age*Cortisol							0.03	0.00	0.05
	CRP*Cortisol							0.07	0.02	0.12	0.0042
	CRP*Age*Cortisol							0.00	−0.01	0.01	0.9804