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. Author manuscript; available in PMC: 2021 Nov 18.
Published in final edited form as: Nat Immunol. 2021 Jul 26;22(8):1020–1029. doi: 10.1038/s41590-021-00979-1

Figure 2. Epigenetic signature of T cell exhaustion is conserved across chronic viral infections.

Figure 2.

(A) Schematic diagram of the experiment. (B) Volcano plot highlighting differential transcripts present in HIV tet+ CD8+ T cells versus naive CD8+ T cells from HIV patients (colored dots, FDR < 0.05). (C) Chromatin accessibility at naïve-specific and HIV-specific ChARs within the indicated conditions from the HCV cohort. (D) Venn diagram of overlap between ChARs with increased in accessibility in HIV and HCV tet+ T cells relative to naïve T cells. (E) Representative ATAC-seq tracks at the ENTPD1 and IL7R gene loci. (F) Gene ontology and gene set enrichment (rows) in Flu-specific (blue) or HCV-specific (red) ChARs. FDR values (hypergeometric test) presented as 1–log10. (G) Heatmap of peak intensity within modules of ChARs (rows) from mouse naïve CD8+ T cells, and CD8+ T cells responding to acute and chronic LCMV (left). Fold enrichment of regions orthologous to mouse naïve, memory and exhaustion enhancers in human samples indicated (right).