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. 2021 Jul 5;80(12):1537–1544. doi: 10.1136/annrheumdis-2021-220435

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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IFNAR depletion on B cells affects B8-specific CD8⁺ T cell responses upon MVA, but not VACV infection. Wild type (WT) and CD19-Cre^+/-IFNAR^flox/flox (IFNAR-B) mice were infected with 10⁵ pfu (A) VACV or (B) MVA. B8-specific CD8⁺ T cells were determined by using an MHC-I multimer. Data shown are pooled from 3 to 4 experiments with n=3–4. Error bars indicate mean±SD; ***p≤0.001; one-tailed Mann-Whitney U test. IFNAR, type I interferon receptor; MVA, modified vaccinia virus Ankara; ns, not significant; VACV, vaccinia virus.