Table 3.

Firth’s penalised Cox regression

Outcome	Covariate	Coef	Exp (coef)	95% CI
MACE	Phenotype, classical Sex, male Phenotype:sex	2.99 2.79 −1.19	19.89* 16.35* 0.31	2.61 to 2554.03 1.94 to 2138.95 0.002 to 2.96
CVD	Phenotype, classical Sex, male Phenotype:sex	2.29 1.88 0.81	9.84† 6.56 2.25	1.13 to 1292.61 0.51 to 916.78 0.01 to 38.56
HF hospitalisation	Phenotype, classical Sex, male Phenotype:sex	2.36 2.35 0.38	10.56† 10.51† 1.47	1.23 to 1383.10 1.08 to 1407.18 0.01 to 22.14
SVA	Phenotype, classical Sex, male Phenotype:sex	1.07 1.81 0.55	2.91 6.14 1.74	0.23 to 404.25 0.58 to 831.73 0.01 to 39.94
MI	Phenotype, classical Sex, male Phenotype:sex	2.42 2.21 −1.28	11.19† 9.12 0.28	1.41 to 1446.63 0.94 to 1221.07 0.00 to 3.26

*P<0.008.

†P<0.05.

coeff, coefficient; CVD, cardiovascular death; HF, heart failure; MACE, major adverse cardiovascular event; MI, myocardial infarction; SVA, sustained ventricular arrhythmia.