Table 4.

HRs for the comparison of different patient groups

Comparison	MACE	CVD	HF	SVA	MI
Men with classical FD versus men with non-classical FD	6.1 (2.4–17.0)*	22.2 (5.0–19.3)*	15.5 (3.7–82.7)*	5.1 (0.9–41.1)	3.1 (1.0–11.7)
Men with classical FD versus women with classical FD	5.0 (2.3–11.0)*	14.8 (4.3–67.0)*	15.4 (4.1–73.8)*	10.7 (1.9–92.0)*	2.5 (1.0–6.7)
Men with non-classical FD versus women with classical FD	0.8 (0.3–2.0)	0.7 (0.1–2.7)	1 (0.3–3.4)	2.1 (0.4–13.0)	0.8 (0.2–2.4)

These HRs where obtained from Firth’s penalised COX regression models in which sex and phenotype where combined in one variable with four patient groups.

*P<0.008.

CVD, cardiovascular death; FD, Fabry disease; HF, heart failure; MACE, major adverse cardiovascular event; MI, myocardial infarction; SVA, sustained ventricular arrhythmia.