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Map of single-step reactions leading to darunavir and montelukast drugs (purple and gray circles) is depicted on the global landscape of the reaction data set B. Clusters 1, 2, and 3 represent some reaction types that can be used for the synthesis of these drugs, but currently, there are no signs that these reactions have been used yet (no gray and purple circles in regions 1, 2, and 3). Therefore, there is an open possibility to extend the landscape of synthetic ways to these drugs.
