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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Ann Rheum Dis. 2020 Oct 7;80(2):228–237. doi: 10.1136/annrheumdis-2020-217840

Figure 1. Clinical and histologic correlates of the Combined Response Index in Systemic Sclerosis (CRISS) ≥ 0.6 (N=18).

Figure 1.

Among 18 individuals with diffuse cutaneous systemic sclerosis with 52-week CRISS ≥ 0.6, (A) clinical and (B) histologic changes in paired baseline and 52-week samples are demonstrated. Boxplots have whiskers from minimum to maximum values, a horizontal line at median value, and box edges at lower (Q1) and upper quartiles (Q3). P-values represent results of Wilcoxon signed-rank test. ****indicates p≤0.0001, ***p≤0.001, **p≤0.01, *p≤0.05. Adjusting for multiple comparisons, local MRSS, total MRSS, physician global assessment, patient global assessment, global histologic severity and CD34 remain statistically significant.