Table 2.

Histologic features underlying local (biopsy-site) modified Rodnan skin scores for 26 individuals with diffuse cutaneous systemic sclerosis contributing 58 skin biopsy samples

Histologic Feature	Local MRSS = 0 (N=3)	Local MRSS = 1 (N=23)	Local MRSS = 2 (N=17)	Local MRSS = 3 (N=15)
Global	0.5 [0, 2.5]	1.5 [0.5, 2.5]	2 [2, 2.5]	2 [2, 3]
aSMA	0 [0, 1]	0.5 [0, 1.5]	1 [0, 2]	2 [1, 2]
CD34	3 [1.5, 3]	2 [1, 3]	1 [1, 2]	1 [0, 1]
Collagen	0 [0, 2.5]	1 [0.5, 2]	2 [1.5, 2.5]	2.5 [2, 3]
Infiltrate	0.5 [0.5, 1]	0.5 [0, 1]	0.5 [0.5, 1]	0.5 [0.5, 1]
Follicles	2 [2, 3]	1 [0, 2]	0 [0, 1]	0 [0, 1]
Thickness	1.9 [1.3, 2]	2.6 [2.1, 3.0]	2.4 [2.1, 2.7]	2.8 [2.2, 3.0]

MRSS=modified Rodnan skin score; aSMA=alpha-smooth muscle actin. Thickness is measured in micrometers from epidermis to subcutis. Median [interquartile range] is reported.