Table 3.

Correlation of 52-week histology change^‡ with CRISS and change in clinical findings among 24 individuals with diffuse cutaneous systemic sclerosis

Histology	CRISS	Total MRSS	Physician Global	Patient Global	HAQ-DI	FVC
Global	−0.52*	0.43 *	0.11	0.07	0.27	−0.31
aSMA	−0.44*	0.46 *	0.20	0.30	0.14	−0.02
CD34	0.53 *	−0.30	−0.42*	−0.46*	−0.51*	0.35
Collagen	−0.44*	0.32	0.09	0.22	0.12	−0.25
Infiltrate	−0.09	0.11	0.04	0.14	0.08	−0.16
Follicles	−0.09	0.23	0.26	0.10	−0.21	0.39
Thickness	−0.20	0.25	0.33	0.41 *	0.13	−0.10

^*Denotes significant p-value <0.05. Spearman correlation coefficients reported.

^‡Histology change categorized as decreased, unchanged, or increased score from baseline to 52-weeks. CRISS=Combined Response Index in Systemic Sclerosis; MRSS=modified Rodnan skin score; HAQ-DI=Health Assessment Questionnaire Disability Index; FVC=%-predicted force vital capacity; aSMA=alpha-smooth muscle actin.