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. Author manuscript; available in PMC: 2022 Sep 10.
Published in final edited form as: J Control Release. 2021 Jul 16;337:179–192. doi: 10.1016/j.jconrel.2021.07.018

Figure 5. Sugar conjugation alters tumor accumulation kinetics of dendrimers and increases tumor specificity.

Figure 5.

Glioblastoma brain tumor-bearing mice were injected intravenously with various dendrimers on day 14 after tumor inoculation. Brains were collected 24 hours after injection, homogenized, and dendrimer content was measured via fluorescence spectrometry. A) Brain tumor-bearing mice injected with glucose- (D-GLU), mannose (D-MAN), and galactose-conjugated dendrimers (D-GAL) exhibit significantly greater tumor accumulation than unmodified dendrimers (D-OH). *** p< 0.001. B) Sugar-conjugated dendrimers exhibit significantly greater specificity for the tumor compared to the contralateral hemisphere than unmodified dendrimers. ** p < 0.01, *** p < 0.001.