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Investigational medicinal products (IMP) used in the HOLPANC trial during neoadjuvant treatment
| IMP | Dosing schedule [Day of 14-day cycle] | Dose [mg/m2] | Route of administration |
|---|---|---|---|
| Liposomal irinotecan (nal-IRI) anhydrous free base* | 1 | 50 | i.v. over about 90 min |
| Oxaliplatin (OX) | 1 | 60 | i.v. over 2 to 6 h |
| Folinic acid (FA) | 1 | 400 | i.v. over about 30 min |
| 5-fluorouracil (5-FU) | 1–2 | 2400 | i.v. over about 46 h |
* Equivalent to 60 mg/m2 irinotecan hydrochloride trihydrate
