Table 2.

Study eligibility criteria defined by PICOTS

PICOTS component	Description
Population	Children (18 years or younger) diagnosed with MPS (all subtypes)
Interventions/exposures	No restrictions on interventions and exposures
Comparators	No restrictions on comparators
Outcomes	No restrictions on outcomes
Time frame	2011-2021
Study design	(i) Non-animal intervention studies of MPS; and (ii) Guidelines for the clinical management of MPS and other guidelines and recommendations related to MPS outcomes

MPS mucopolysaccharidosis, PICOTS population, interventions/exposures, comparators, outcomes, time frame, and study design