Fig. 6.

A–G: Prevalence of the top ten most common mutations for the constituent proteins of the RNA-dependent RNA polymerase (RdRP) complex, by collection date in one-week intervals beginning on January 5th, 2020 and ending on January 16th, 2021. The top ten mutations A) worldwide, B) in Europe, C) in Asia, D) in North America, E) in Africa, F) in Oceania, and G) in South America, are shown. Mutations that appear within the top ten most prevalent mutations on multiple continents are given the same color and shape in every graph. The combination and prevalence of mutations present varies by continent, with the Nsp12 substitution P323L being most common on all continents, and most other mutations present in less than 20% of samples from each continent. Exceptions include the Nsp12 finger subdomain substitution A423V, which was common in Asia during July and August 2020, and the Nsp7 substitution L71F, which was common in South America during October and November 2020. Nearly all mutations besides the Nsp12 substitution P323L have either peaked and subsequently decreased in prevalence, or have plateaued at low prevalence values of 5–10%.