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. 2021 Nov 17;19:374. doi: 10.1186/s12951-021-01119-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of PCM/RAP and MM@PCM/RAP. a Schematic illustration of preparation and drug release of MM@PCM/RAP. b The hydrated particle size and c zeta potential of PCM/RAP, MM@PCM/RAP and MM (n = 3, mean ± SD). d TEM images of PCM/RAP and MM@PCM/RAP (scale bar = 50 nm). e Western blot analysis of CCR2, Integrin α4, Integrin β1 and CD47 in Macrophage, MM and MM@PCM/RAP. f In vitro drug release study of PCM/RAP and MM@PCM/RAP without and with 10 μM H₂O₂ (n = 3, mean ± SD)