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. 2021 Nov 18;14:196. doi: 10.1186/s13045-021-01212-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LncRNA Snhg6 promotes Mo-MDSCs but not affects the differentiation of PMN-MDSCs. a LncRNA Snhg6 expression in Tu-MDSCs compared with SP-MDSCs measured by qRT-PCR. b, c Typical flow cytometry of CD11b⁺ Gr-1⁺ MDSCs. d–g The percentage and absolute number of CD11b⁺ Gr-1⁺ MDSCs by statistical analyses. h, i Typical flow cytometry and the percentage of CD11b⁺ Ly6G⁺ Ly6C^low PMN-MDSCs and CD11b⁺ Ly6G⁻ Ly6C^high Mo-MDSCs after downregulating the expression of lncRNA Snhg6. j, k Typical flow cytometry and percentage of CD11b⁺ Ly6G⁺ Ly6C^low PMN-MDSCs and CD11b⁺ Ly6G⁻ Ly6C^high Mo-MDSCs after increasing the expression of lncRNA Snhg6. Each expression had three replicates, ns: no significance; * p < 0.05; ** p < 0.01