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. 2021 Nov 17;19:370. doi: 10.1186/s12951-021-01117-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Increased number of PCNA- and Ki-67-positive cells in mouse lungs after Nano-Ni exposure by immunohistochemical staining. Mice were instilled intratracheally with 50 µg per mouse of Nano-Ni. Control mice were instilled with physiological saline. Lung tissues were collected at day 7 (D7) and day 42 (D42) after Nano-Ni exposure. A, E, and I show the normal structure of lung parenchyma in a control mouse. Increased number of PCNA (F–H) and Ki-67 (J-L) positive cells (brown staining) were observed in the mouse lungs after Nano-Ni exposure. Scale bars represent 50 µm for all panels