Table 1.
Mutant frequency (MF) of gpt gene in mouse lungs
| Treatment | Sex | No. of rescued colonies | No. of mutants | MF (× 10−6) | Average of MF ± SEM (× 10−6) |
|---|---|---|---|---|---|
| Control | F | 477,000 | 5 | 10.5 | |
| F | 540,000 | 9 | 16.7 | ||
| M | 229,500 | 2 | 8.7 | ||
| M | 1,429,500 | 15 | 10.5 | 11.6 ± 1.8 | |
| Nano-Ni | F | 697,500 | 3 | 4.3 | |
| F | 529,500 | 4 | 7.6 | ||
| M | 369,000 | 9 | 24.4 | ||
| M | 844,500 | 9 | 10.7 | ||
| M | 2,004,000 | 12 | 6.0 | 10.6 ± 3.6 |
gpt delta transgenic mice were instilled intratracheally with 50 µg per mouse of Nano-Ni. Control mice were instilled with physiological saline. Lung tissues were collected at four months after instillation