Table 1.

Allele frequency database prevalence and carrier frequency calculations

	prevalence		carrier frequency
	known and novel variants	known variants	known and novel variants	known variants
total	1.10152 (0.890567, 1.370326)	0.428407 (0.3357, 0.554897)	0.002097	0.001308
AFR	5.639105 (3.010004, 10.55961)	0.944298 (0.355737, 2.505441)	0.004738	0.001942
AMR	1.482111 (0.812177, 2.704048)	0.565474 (0.263468, 1.213389)	0.002432	0.001503
ASJ	0.046311 (0.003816, 0.561623)	0	0.00043	0
EAS	1.676507 (0.755126, 3.720573)	0.781969 (0.298701, 2.046257)	0.002586	0.001767
FIN	0.00864 (0.000654, 0.114046)	0	0.000186	0
NFE	1.143383 (0.595458, 1.961721)	0.593037 (0.239053, 1.177138)	0.002136	0.001539
SAS	1.121036 (0.56517, 2.22306)	0.436036 (0.183617, 1.035195)	0.002115	0.00132
OTH	0.731709 (0.138862, 3.850784)	0.107322 (0.008125, 1.415878)	0.001709	0.000655

AFR African/African American, AMR Latino/Mixed American, ASJ Ashkenazi Jewish, EAS East Asian, FIN Finnish, NFE Non-Finnish European, SAS South Asian, OTH Other